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Cancer Lett. 2011 Sep 28;308(2):181-8. doi: 10.1016/j.canlet.2011.05.002. Epub 2011 Jun 14.

Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway.

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1
Department of Surgery, University of Minnesota, Minneapolis, 55455, United States.

Abstract

Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.

PMID:
21676539
PMCID:
PMC3126884
DOI:
10.1016/j.canlet.2011.05.002
[Indexed for MEDLINE]
Free PMC Article
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