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Croat Med J. 2011 Jun;52(3):336-43.

Genetic analysis of 7 medieval skeletons from the Aragonese Pyrenees.

Author information

1
Department of Forensic Medicine, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. carolina@unizar.es

Abstract

AIM:

To perform a genetic characterization of 7 skeletons from medieval age found in a burial site in the Aragonese Pyrenees.

METHODS:

Allele frequencies of autosomal short tandem repeats (STR) loci were determined by 3 different STR systems. Mitochondrial DNA (mtDNA) and Y-chromosome haplogroups were determined by sequencing of the hypervariable segment 1 of mtDNA and typing of phylogenetic Y chromosome single nucleotide polymorphisms (Y-SNP) markers, respectively. Possible familial relationships were also investigated.

RESULTS:

Complete or partial STR profiles were obtained in 3 of the 7 samples. Mitochondrial DNA haplogroup was determined in 6 samples, with 5 of them corresponding to the haplogroup H and 1 to the haplogroup U5a. Y-chromosome haplogroup was determined in 2 samples, corresponding to the haplogroup R. In one of them, the sub-branch R1b1b2 was determined. mtDNA sequences indicated that some of the individuals could be maternally related, while STR profiles indicated no direct family relationships.

CONCLUSIONS:

Despite the antiquity of the samples and great difficulty that genetic analyses entail, the combined use of autosomal STR markers, Y-chromosome informative SNPs, and mtDNA sequences allowed us to genotype a group of skeletons from the medieval age.

PMID:
21674829
PMCID:
PMC3118721
[Indexed for MEDLINE]
Free PMC Article
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