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Biofactors. 2011 Sep-Oct;37(5):366-73. doi: 10.1002/biof.154. Epub 2011 Jun 14.

Coenzyme Q(10) , endothelial function, and cardiovascular disease.

Author information

1
Department of Biochemistry, Biology & Genetics, Marche Polytechnic University, Ancona, Italy. g.littarru@univpm.it

Abstract

Since the time a precise role of coenzyme Q(10) (CoQ(10) ) in myocardial bioenergetics was established, the involvement of CoQ in the pathophysiology of heart failure was hypothesized. This provided the rationale for numerous clinical trials of CoQ(10) as adjunctive treatment for heart failure. A mild hypotensive effect of CoQ was reported in the early years of clinical use of this compound. We review early human and animal studies on the vascular effects of CoQ. We then focus on endothelial dysfunction in type 2 diabetes and the possible impact on this condition of antioxidants and nutritional supplements, and in particular the therapeutic effects of CoQ. The effect of CoQ(10) on endothelial dysfunction in ischemic heart disease is also reviewed together with recent data highlighting that treatment with CoQ(10) increases extracellular SOD activity.

PMID:
21674640
DOI:
10.1002/biof.154
[Indexed for MEDLINE]

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