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Int J Mol Sci. 2011;12(3):2055-63. doi: 10.3390/ijms12032055. Epub 2011 Mar 22.

Circulating microRNAs: potential biomarkers for cancer.

Author information

1
Institute of Hepatobiliary Surgery, Nanjing University, Nanjing, Jiangsu, China; E-Mails: dryudecai@hotmail.com (D.-C.Y.); lqg0235062@163.com (Q.-G.L.); dxw0008@sina.com (X.-W.D.).

Abstract

Cancer is the leading cause of death in the world. Development of minimally invasive biomarkers for early detection of cancer is urgently needed to reduce high morbidity and mortality associated with malignancy. MicroRNAs (miRNAs) are small regulatory RNAs that modulate the activity of specific mRNA targets and play important roles in a wide range of physiologic and pathologic processes. Recently, miRNAs were found to be dysregulated in a variety of diseases including cancer. Emerging evidence suggests that miRNAs are involved in tumor initiation and progression. Together, the different expression profiles of miRNAs in cancer, and the stability of circulating miRNAs, make them new potentially clinical biomarkers for cancer diagnosis, classification, therapeutic decisions, and prognosis.

KEYWORDS:

biomarkers; circulation; microrna; neoplasm

PMID:
21673939
PMCID:
PMC3111650
DOI:
10.3390/ijms12032055
[Indexed for MEDLINE]
Free PMC Article

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