Abstract
EMBO J 30 12, 2325–2335 (2011); published online May 10 2011
The Hippo (Hpo) signalling pathway is an evolutionarily conserved pathway controlling tissue growth, but its upstream inputs remain poorly understood. In this issue of The EMBO Journal, Sansores-Garcia et al (2011) report that modulation of filamentous (F)-actin accumulation controls Hpo pathway activity. In a related study, Garcia-Fernandez et al (2011) confirm this finding, and also show that the Hpo pathway itself can modulate F-actin levels. Such actin-dependent regulation of Hpo pathway activity has relevance to the control of tissue growth by epithelial architecture and external tension cues.
Publication types
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Research Support, Non-U.S. Gov't
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Review
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Comment
MeSH terms
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Actins / antagonists & inhibitors
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Actins / metabolism
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Actins / physiology*
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Active Transport, Cell Nucleus / physiology
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Animals
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Cell Communication / physiology
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Cells, Cultured
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Drosophila Proteins / antagonists & inhibitors
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Drosophila Proteins / metabolism*
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Drosophila Proteins / physiology
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Intracellular Signaling Peptides and Proteins / antagonists & inhibitors
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Intracellular Signaling Peptides and Proteins / metabolism*
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Intracellular Signaling Peptides and Proteins / physiology
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Nuclear Proteins / antagonists & inhibitors
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Nuclear Proteins / metabolism
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Oogenesis / physiology
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Protein Serine-Threonine Kinases / antagonists & inhibitors
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Protein Serine-Threonine Kinases / metabolism*
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Protein Serine-Threonine Kinases / physiology
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Signal Transduction / physiology*
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Trans-Activators / antagonists & inhibitors
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Trans-Activators / metabolism
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YAP-Signaling Proteins
Substances
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Actins
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Drosophila Proteins
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Intracellular Signaling Peptides and Proteins
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Nuclear Proteins
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Trans-Activators
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YAP-Signaling Proteins
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Yki protein, Drosophila
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Protein Serine-Threonine Kinases
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hpo protein, Drosophila