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AIDS. 2011 Aug 24;25(13):1668-70. doi: 10.1097/QAD.0b013e3283498305.

Frequency of CXCR4-using viruses in primary HIV-1 infections using ultra-deep pyrosequencing.

Author information

1
INSERM U, Toulouse, France.

Abstract

We used ultra-deep pyrosequencing and the Toulouse Tropism Test phenotypic assay to determine the prevalence of CXCR4-using viruses in 21 patients with primary HIV-1 infections. We found X4-containing virus populations in 9% of patients by ultra-deep pyrosequencing using position-specific scoring matrices (PSSM(X4/R5)) or geno2pheno(5.75) and in 14% using the combined 11/25 and net charge rule. The phenotypic assay identified 9% of CXCR4-using viruses. This confirms that R5 viruses are predominant in primary HIV-1 infections.

PMID:
21673557
DOI:
10.1097/QAD.0b013e3283498305
[Indexed for MEDLINE]

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