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Free Radic Res Commun. 1990;9(3-6):399-405.

Principles of the metabolism of nitroxides and their implications for spin trapping.

Author information

1
University of Illinois College of Medicine at Urban-Champaign 61801.

Abstract

A review of the principal interactions of nitroxides with cells suggests that if these same phenomena occur with spin adducts the result could be considerable experimental confusion and error. In particular, these could lead to differential rates of loss of spin adducts, thereby potentially invalidating conclusions on the amounts or even the types of free radicals that are trapped. In addition, shuttling of electrons between nitroxides and hydroxylamines also very significantly could alter the amounts and types of spin adducts that are observed.

PMID:
2167277
DOI:
10.3109/10715769009145700
[Indexed for MEDLINE]

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