Format

Send to

Choose Destination
Eur Neuropsychopharmacol. 2012 Feb;22(2):81-91. doi: 10.1016/j.euroneuro.2011.05.005. Epub 2011 Jun 14.

Mechanisms of neuropathic pain.

Author information

1
Department of Neurology, University of Erlangen-Nuremberg, Germany.

Abstract

Neuropathic pain is a disease of global burden. Its symptoms include spontaneous and stimulus-evoked painful sensations. Several maladaptive mechanisms underlying these symptoms have been elucidated in recent years: peripheral sensitization of nociception, abnormal excitability of afferent neurons, central sensitization comprising pronociceptive facilitation, disinhibition of nociception and central reorganization processes, and sympathetically maintained pain. This review aims to illustrate these pathophysiological principles, focussing on molecular and neurophysiological findings. Finally therapeutic options based on these findings are discussed.

PMID:
21672666
DOI:
10.1016/j.euroneuro.2011.05.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center