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Acta Paediatr. 2012 Jan;101(1):e39-42. doi: 10.1111/j.1651-2227.2011.02382.x. Epub 2011 Jun 29.

Inappropriate antidiuretic hormone secretion: long-term successful urea treatment.

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Paediatric Department, Paediatric Nephrology Unit, University Hospital, Lausanne, Switzerland.


Hyponatremia is the main complication of inappropriate antidiuretic hormone secretion (SIADH), sometimes fatal. Treatment strategy depends on the cause and the severity of the hyponatremia. Recent studies have shown the efficacy of urea in treating acute hyponatremia secondary to SIADH, by inducing an osmotic water drive. We describe an infant with chronic hyponatremia secondary to SIADH in which the long-term oral treatment with urea was successful and well tolerated. The aim of this paper is to highlight the potential benefits of urea treatment in case of chronic hyponatremia secondary to SIADH.


Chronic oral urea treatment in children with SIADH allows an easy and safe water and sodium control and may permit a decrease in fluid restriction in this situation.

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