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Int J Eat Disord. 2012 Apr;45(3):345-52. doi: 10.1002/eat.20944. Epub 2011 Jun 13.

Serotonin transporter binding after recovery from bulimia nervosa.

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  • 1Department of Radiology, University of California, San Diego, California, USA.

Abstract

OBJECTIVE:

Physiological and pharmacological studies indicate that altered brain serotonin (5-HT) activity could contribute to a susceptibility to develop appetitive and behavioral alterations that are characteristic of bulimia nervosa (BN).

METHOD:

Eight individuals recovered from BN (REC BN) and eight healthy control women were scanned with [11C]DASB and positron emission tomography imaging of the 5-HT transporter (5-HTT). Logan graphical analysis was applied, and parametric binding potential (BP(nondisplaceable (ND)) ) images were generated. Voxel-by-voxel t-tests and a region of interest (ROI) analysis were conducted.

RESULTS:

REC BN had significantly lower [11C]DASB BP(ND) in midbrain, superior and inferior cingulate and significantly higher [11C]DASB BP(ND) in anterior cingulate and superior temporal gyrus in the voxel-based analysis. ROI analysis indicated lower [11C]DASB BP(ND) in midbrain (p = .07), containing the dorsal raphe, in REC BN, consistent with our earlier studies.

DISCUSSION:

These preliminary findings of a small-scale study confirm and extend previous data suggesting that ill and recovered BN have altered 5-HTT measures, which potentially contribute to BN symptomatology and/or differential responses to medication.

PMID:
21671458
PMCID:
PMC3175264
DOI:
10.1002/eat.20944
[PubMed - indexed for MEDLINE]
Free PMC Article
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