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Am J Med Genet A. 2011 Jul;155A(7):1680-4. doi: 10.1002/ajmg.a.34058. Epub 2011 Jun 10.

Adults with Rubinstein-Taybi syndrome.

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1
Department of Pediatrics, University of Tennessee College of Medicine, Chattanooga, USA. cathy.stevens@erlanger.org

Abstract

Information in the medical literature regarding adults with genetic syndromes is limited, making the care of these patients challenging. We conducted a questionnaire study of adults with Rubinstein-Taybi syndrome that addressed medical problems, education, independence, and behavior. The most common medical problems included short stature, obesity, visual difficulties, keloids, eating problems, spine curvature, and joint problems. The adults had typically moderate mental retardation, but most achieved some independence in self-care and communication; many participated in supported work situations. However, approximately one-third were said to have some decreased abilities over time. Behavior problems were common and often worsened with age. Very few of the study participants were seeing a geneticist as an adult. Long-term involvement of geneticists and education of adult primary care providers may help with many of the challenges facing adults with RTS and their families.

PMID:
21671385
DOI:
10.1002/ajmg.a.34058
[Indexed for MEDLINE]
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