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Physiology (Bethesda). 2011 Jun;26(3):192-205. doi: 10.1152/physiol.00046.2010.

The regulation and physiology of mitochondrial proton leak.

Author information

1
Medical Research Council Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge, United Kingdom.

Abstract

Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.

PMID:
21670165
DOI:
10.1152/physiol.00046.2010
[Indexed for MEDLINE]
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