3-Methoxy-2-methyl-carbazole-1,4-quinone, carbazomycins D and F from Streptomyces sp. CMU-JT005

FEMS Microbiol Lett. 2011 Sep;322(1):77-81. doi: 10.1111/j.1574-6968.2011.02335.x. Epub 2011 Jul 13.

Abstract

3-Methoxy-2-methyl-carbazole-1,4-quinone (1) together with carbazomycins D (2) and F (3) were isolated from the crude extract of Streptomyces CMU-JT005, an actinomycete with nematicidal activity. 3-Methoxy-2-methyl-carbazole-1,4-quinone is reported here for the first time from nature. In this paper, we describe the isolation and structure elucidation of the compounds together with the characterization of the Streptomyces strain CMU-JT005.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antinematodal Agents / chemistry
  • Antinematodal Agents / isolation & purification
  • Antinematodal Agents / metabolism
  • Carbazoles / chemistry
  • Carbazoles / isolation & purification
  • Carbazoles / metabolism
  • Molecular Structure
  • Quinones / chemistry
  • Quinones / isolation & purification
  • Quinones / metabolism*
  • Soil Microbiology
  • Streptomyces / chemistry
  • Streptomyces / genetics
  • Streptomyces / isolation & purification
  • Streptomyces / metabolism*

Substances

  • Antinematodal Agents
  • Carbazoles
  • Quinones
  • carbazomycin F
  • carbazomycin D