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J Womens Health (Larchmt). 2011 Jul;20(7):983-9. doi: 10.1089/jwh.2010.2662. Epub 2011 Jun 13.

Diabetes and depression in pregnancy: is there an association?

Author information

1
Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington 98195, USA. jkaton@u.washington.edu

Abstract

BACKGROUND:

Prior studies have reported inconsistent findings regarding the association of antenatal depression with pregnancy-related diabetes. This study examined the association of diabetes and antenatal depression.

METHODS:

We conducted a cross-sectional analysis of baseline data from a prospective cohort study of pregnant women receiving prenatal care at a single University of Washington Medical Center clinic between January 2004 and January 2009. The primary exposure was diabetes in pregnancy (no diabetes, preexisting diabetes, or gestational diabetes [GDM]). Antenatal depression was defined by the Patient Health Questionnaire-9 (PHQ-9) score or current use of antidepressants. Antenatal depression was coded as (1) any depression (probable major or minor depression by PHQ-9 or current antidepressant use) and (2) major depression (probable major depression by PHQ-9 or current antidepressant use). Logistic regression was used to quantify the association between diabetes in pregnancy and antenatal depression.

RESULTS:

The prevalences of preexisting diabetes, GDM, any antenatal depression, and major antenatal depression were 9%, 18%, 13.6%, and 9.8%, respectively. In the unadjusted analysis, women with preexisting diabetes had 54% higher odds of any antenatal depression compared to those without diabetes (odds ratio [OR] 1.54, 95% confidence interval [CI] 1.08-2.21). After adjusting for important covariates the association was attenuated (OR 1.16, 95% CI 0.79-1.71). Results were similar for antenatal major depression. GDM was not associated with increased odds for any antenatal depression or antenatal major depression.

CONCLUSIONS:

Neither preexisting diabetes nor GDM was independently associated with increased risk of antenatal depression.

PMID:
21668382
PMCID:
PMC3130515
DOI:
10.1089/jwh.2010.2662
[Indexed for MEDLINE]
Free PMC Article
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