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Eur J Pharmacol. 1990 Jun 8;181(3):323-6.

Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.

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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.


The effect of recombinant human interleukin 1-beta (IL-1 beta) on long-term potentiation (LTP) in the mossy fiber-CA3 pathway of mouse hippocampal slice preparations was investigated. IL-1 beta significantly inhibited LTP in concentrations as low as 2.9 pM (50 pg/ml). This effect of IL-1 beta was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-1 beta. This is the first evidence that IL-1 beta can regulate LTP of synaptic transmission in the hippocampus.

[Indexed for MEDLINE]

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