Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Pharmacol. 1990 Jun 8;181(3):323-6.

Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.

Author information

  • 1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

Abstract

The effect of recombinant human interleukin 1-beta (IL-1 beta) on long-term potentiation (LTP) in the mossy fiber-CA3 pathway of mouse hippocampal slice preparations was investigated. IL-1 beta significantly inhibited LTP in concentrations as low as 2.9 pM (50 pg/ml). This effect of IL-1 beta was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-1 beta. This is the first evidence that IL-1 beta can regulate LTP of synaptic transmission in the hippocampus.

PMID:
2166677
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center