Protein interactions with surfaces: Computational approaches and repellency

Luisa Mayorga Szott; Thomas A Horbett

doi:10.1016/j.cbpa.2011.04.016

Protein interactions with surfaces: Computational approaches and repellency

Curr Opin Chem Biol. 2011 Oct;15(5):683-9. doi: 10.1016/j.cbpa.2011.04.016. Epub 2011 Jun 12.

Authors

Luisa Mayorga Szott¹, Thomas A Horbett

Affiliation

¹ Department of Bioengineering, University of Washington, Seattle, WA 98195-5061, USA.

PMID: 21665520
DOI: 10.1016/j.cbpa.2011.04.016

Abstract

Study of protein adsorption to solid surfaces continues to be substantial because of its role in cellular responses to biomaterials, interest in molecular aspects such as conformation and orientation, new methods for making protein repellent surfaces, and new application areas such as nanoparticles and microfluidics. This brief review is based only on very recent articles of particular interest to the authors, who each have worked in this area for some time. Simulations of protein interactions with surfaces and protein repellent surfaces are the only subtopics reviewed here.

Publication types

Review

MeSH terms

Adsorption
Biocompatible Materials / analysis*
Biocompatible Materials / chemistry
Biocompatible Materials / metabolism
Humans
Hydrophobic and Hydrophilic Interactions
Methacrylates / analysis
Methacrylates / chemistry
Methacrylates / metabolism
Molecular Dynamics Simulation*
Monte Carlo Method
Nanotechnology / methods*
Polyethylene Glycols / analysis*
Polyethylene Glycols / chemistry
Polyethylene Glycols / metabolism
Protein Conformation
Proteins / analysis*
Proteins / chemistry
Proteins / metabolism
Surface Properties
Thermodynamics

Substances

Biocompatible Materials
Methacrylates
Proteins
polyethylene glycol methacrylate
Polyethylene Glycols