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Mol Cell Endocrinol. 2011 Dec 5;347(1-2):42-7. doi: 10.1016/j.mce.2011.05.024. Epub 2011 Jun 1.

Vitamin D metabolism within bone cells: effects on bone structure and strength.

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Endocrine Bone Research Laboratory, Chemical Pathology, SA Pathology, Adelaide, SA 5000, Australia.


The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to metabolise 25-hydroxyvitamin D (25(OH)D(3)) to 1,25(OH)(2)D(3), which in turn exerts autocrine/paracrine actions to regulate bone cell proliferation and maturation as well as bone mineralisation and resorption. In vivo and in vitro studies indicate that these autocrine/paracrine activities of 1,25(OH)(2)D(3) in bone tissue contribute to maintaining bone mineral homeostasis and enhancing skeletal health.

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