Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2011 Jun 10;145(6):956-68. doi: 10.1016/j.cell.2011.05.003.

Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye.

Author information

1
Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA.

Abstract

How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of photoreceptors. Here, we describe a role for the transcription factor gene defective proventriculus (dve) as a critical node in the network regulating Rhodopsin expression. dve is a shared component of two opposing, interlocked feedforward loops (FFLs). Orthodenticle and Dve interact in an incoherent FFL to repress Rhodopsin expression throughout the eye. In R7 and R8 photoreceptors, a coherent FFL relieves repression by Dve while activating Rhodopsin expression. Therefore, this network uses repression to restrict and combinatorial activation to induce cell-type-specific expression. Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification.

PMID:
21663797
PMCID:
PMC3117217
DOI:
10.1016/j.cell.2011.05.003
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center