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Mol Brain. 2011 Jun 13;4:26. doi: 10.1186/1756-6606-4-26.

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance.

Author information

1
Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.

Abstract

Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.

PMID:
21663703
PMCID:
PMC3138392
DOI:
10.1186/1756-6606-4-26
[Indexed for MEDLINE]
Free PMC Article

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