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Open Cardiovasc Med J. 2011;5:76-84. doi: 10.2174/1874192401105010076. Epub 2011 Feb 24.

Effects of thyroid dysfunction on lipid profile.

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Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.


Thyroid dysfunction has a great impact on lipids as well as a number of other cardiovascular risk factors. Hypothyroidism is relatively common and is associated with an unfavorable effect on lipids. Substitution therapy is beneficial for patients with overt hypothyroidism, improving lipid profile. However, whether subclinical hypothyroidism should be treated or not is a matter of debate. On the other hand, hyperthyroidism can be associated with acquired hypocholesterolemia or unexplained improvement of lipid profile. Overall, thyroid dysfunction should be taken into account when evaluating and treating dyslipidemic patients.


Cardiovascular disease; dyslipidemia; hyperthyroidism; hypothyroidism; lipoprotein (a); thyroid autoimmunity; thyroid dysfunction; thyroxine treatment.

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