Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurodegener Dis. 2011;8(6):483-90. doi: 10.1159/000327754. Epub 2011 Jun 9.

Suicidal behavior in prodromal Huntington disease.

Author information

1
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

Abstract

BACKGROUND:

Several studies have suggested a greater risk of suicide in Huntington disease (HD); however, unique risk factors for suicide in HD are not established.

OBJECTIVE:

We sought to determine risk factors for suicidal behavior, defined as suicide or attempted suicide, in prodromal HD.

METHODS:

From the prospective PREDICT-HD cohort, we identified 735 cases with HD gene expansion but no manifest symptoms of HD and 194 non-gene-expanded controls. In survival analysis, a number of potential risk factors for suicidal behavior were assessed, including symptoms of depression, hopelessness, substance abuse, marital status, gender, and psychiatric history.

RESULTS:

During a mean of 3.7 years of prospective follow-up, 12 cases (1.6%) attempted suicide and 1 completed suicide (0.1%). No suicides were observed among controls. In univariate Cox proportional hazards regression models, a history of suicide attempts (HR 8.5, 95% CI 2.8-26.1, p < 0.0002) and a Beck Depression Inventory II score >13 (HR 7.2, 95% CI 2.3-22.0, p < 0.0006) were associated with suicidal behavior. These risk factors had independent effects in multivariate models. A history of incarceration in the past 2 years was also associated (HR 12.5, 95% CI 2.7-56.6, p < 0.002), though uncommon. No further risk factors were identified.

CONCLUSION:

A history of suicide attempts and the presence of depression are strongly predictive of suicidal behavior in prodromal HD. As these risk factors are among the most robust risk factors for suicide, established suicide risk factors appear applicable to those with prodromal HD.

PMID:
21659725
PMCID:
PMC3186721
DOI:
10.1159/000327754
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Support Center