Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2011 Aug;27(8):362-70. doi: 10.1016/j.pt.2011.04.004. Epub 2011 Jun 12.

Why RIDL is not SIT.

Author information

1
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, USA. wcb4@lamar.colostate.edu

Abstract

History teaches that sterile insect technique (SIT) is a feasible strategy for mosquito population suppression. Female killing (FK) technologies developed later theoretically had greater potential than SIT, but depended upon chromosomal translocations. Unfortunately these were genetically unstable. New transgenic strategies have been misinterpreted as a replacement for SIT. Instead these strategies provide a means to revisit FK. Conditional lethal mutations inserted into mosquito genomes allow for adjustment of the age of mortality, female-specific lethality, bisexual lethality and manipulation of germline-specific gene expression. A recent Aedes aegypti case study demonstrates the viability of one of these new transgenic strategies.

PMID:
21659002
DOI:
10.1016/j.pt.2011.04.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center