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ACS Nano. 2011 Jul 26;5(7):5755-62. doi: 10.1021/nn2014479. Epub 2011 Jun 15.

Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure.

Author information

1
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.

Abstract

Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function.

PMID:
21657201
PMCID:
PMC3170729
DOI:
10.1021/nn2014479
[Indexed for MEDLINE]
Free PMC Article

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