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Ther Umsch. 2011 Jun;68(6):309-13. doi: 10.1024/0040-5930/a000170.

[Amiodarone and thyroid].

[Article in German]

Author information

1
Klinik für Innere Medizin, Stadtspital Triemli, Zürich.

Abstract

Amiodarone is a widely used antiarrythmic drug and can lead either to hypothyroidism or hyperthyroidism due to its molecular structure which is similar to levothyroxin. Amiodarone induced hypothyroidism can be treated easely with hormonal subsitution. Hyperthyroidism is more challenging. There exist two forms of amiodarone-induced Hyperthyroidism (AIT): AIT type 1 is directly related to the iodine compound of amiodarone and responds to thyreostatic therapy. Type 2 is a consequence of the direct toxicity of amiodarone to the thyroid gland and is treated primarily with glucocorticoids. However, this differentiation often is impossible in clinical settings and a pragmatic approach is needed.

PMID:
21656489
DOI:
10.1024/0040-5930/a000170
[Indexed for MEDLINE]
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