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Cancer Causes Control. 2011 Aug;22(8):1133-9. doi: 10.1007/s10552-011-9789-5. Epub 2011 Jun 9.

Intake of whole-grain products and risk of prostate cancer among men in the Danish Diet, Cancer and Health cohort study.

Author information

1
Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark. egeberg@cancer.dk

Abstract

OBJECTIVE:

High intake of whole-grain products may protect against prostate cancer, but overall evidence is limited and inconclusive. The aim of the present study was to investigate the relationship between the intake of whole-grain products and risk of prostate cancer in a large prospective cohort.

METHODS:

A total of 26,691 men aged 50-64 years participated in the Diet, Cancer and Health cohort study and provided information about diet and potential prostate cancer risk factors. During a median follow-up of 12.4 years, we identified 1,081 prostate cancer cases. Associations between whole-grain product intake and prostate cancer incidence were analyzed using Cox's regression model.

RESULTS:

Overall, there was no association between total intake of whole-grain products and prostate cancer risk (adjusted incidence rate ratio per 50 g day(-1): 1.00 (95% confidence interval: 0.96, 1.05)) as well as between intake of the specific whole-grain products: whole-grain rye bread, whole-grain bread, and oatmeal, and risk of prostate cancer. No risk estimates did differ according to either stage or grade of disease.

CONCLUSIONS:

Results from this prospective study suggest that higher intakes of total or specific whole-grain products are not associated with risk of prostate cancer in a population of Danish middle-aged men.

PMID:
21656162
DOI:
10.1007/s10552-011-9789-5
[Indexed for MEDLINE]

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