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Proc Natl Acad Sci U S A. 1990 Aug;87(15):5812-6.

A distinctive family of embryonic protein-tyrosine kinase receptors.

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1
Department of Biology, University of California, San Diego, La Jolla 92093.

Abstract

Two closely related protein-tyrosine kinases with the characteristics of growth factor receptors were identified by screening a chicken embryo cDNA expression library with anti-phosphotyrosine antibodies and were designated Cek2 and Cek3 (chicken embryo kinases 2 and 3). Cek2 and Cek3 are structurally related to Cek1, a chicken basic fibroblast growth factor receptor, and presumably represent receptors for basic fibroblast growth factor-related molecules. The identification of Cek2 and Cek3 establishes the existence of a family of protein-tyrosine kinases that includes Cek1 and that is likely to be implicated in the control of developmental processes. Among protein-tyrosine kinases, this family of receptors, which may include other as yet unknown members, is most closely related to the protooncogene product Ret and the platelet-derived growth factor receptor family.

PMID:
2165604
PMCID:
PMC54418
[Indexed for MEDLINE]
Free PMC Article
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