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PLoS Biol. 2011 May;9(5):e1001074. doi: 10.1371/journal.pbio.1001074. Epub 2011 May 31.

Towards a functional understanding of protein N-terminal acetylation.

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1
Department of Molecular Biology, University of Bergen, Bergen, Norway. thomas.arnesen@mbi.uib.no

Abstract

Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein-protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.

PMID:
21655309
PMCID:
PMC3104970
DOI:
10.1371/journal.pbio.1001074
[Indexed for MEDLINE]
Free PMC Article
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