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Curr Oncol. 2011 Jun;18(3):e158-62.

Radiotherapy for steroid-resistant laryngeal Rosai-Dorfman disease.

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University of Western Ontario, Schulich School of Medicine and Dentistry, London, ON.


Rosai-Dorfman disease is a rare lymphoproliferative disorder that can have nodal and extranodal manifestations. In the absence of established guidelines for the management of this condition, various therapeutic modalities are used, including radiotherapy. Radiation dosages and fractionation schedules have not been reported in all instances. We present a case in which glottic and subglottic Rosai-Dorfman lesions causing airway obstruction in a frail steroid-refractory patient were put into complete remission using radiotherapy. The lesions responded transiently to a course of prednisone, but responded completely to external-beam radiation, with minimal side effects to the patient.


Rosai–Dorfman disease; histiocytosis with massive lymphadenopathy; radiotherapy

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