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J Pediatr Orthop. 2011 Jul-Aug;31(5):577-86. doi: 10.1097/BPO.0b013e31821c7738.

Glycobiology and the growth plate: current concepts in multiple hereditary exostoses.

Author information

1
Department of Orthopaedic Surgery, Center for Children's Cancer Research, Huntsman Cancer Institute, Primary Children's Medical Center, University of Utah, Salt Lake City, UT, USA.

Abstract

BACKGROUND:

Multiple hereditary exostoses, also termed as multiple osteochondromas, is a heritable disorder of connective tissue with primarily orthopaedic clinical manifestations. Understanding of its biological underpinnings has been advanced on a variety of fronts in recent years.

METHODS:

The multifaceted literature regarding osteochondromagenesis and the major clinical challenges in patients with multiple osteochondromas were reviewed.

RESULTS:

Consideration of recent advances in molecular biology, biochemistry, and animal modeling of osteochondroma pathogenesis yields a unified model.

CONCLUSIONS:

Mechanistic details and therapeutic targets have yet to be elucidated, but the general biology of osteochondroma formation is increasingly clear, as well as its implications in the orthopaedic clinical setting.

PMID:
21654469
PMCID:
PMC3111916
DOI:
10.1097/BPO.0b013e31821c7738
[Indexed for MEDLINE]
Free PMC Article

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