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J Clin Microbiol. 2011 Aug;49(8):2976-9. doi: 10.1128/JCM.00293-11. Epub 2011 Jun 8.

Genetic characterization of multidrug-resistant, extended-spectrum- β-lactamase-producing Vibrio cholerae O1 outbreak strains, Mpumalanga, South Africa, 2008.

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1
Enteric Diseases Reference Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Private Bag X4, Sandringham, 2131 Johannesburg, South Africa.

Abstract

Thirty-one antimicrobial-resistant, extended-spectrum-β-lactamase-producing strains of Vibrio cholerae O1 serotype Ogawa associated with an outbreak of cholera in South Africa (2008) were investigated. Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 β-lactamase.

PMID:
21653763
PMCID:
PMC3147719
DOI:
10.1128/JCM.00293-11
[Indexed for MEDLINE]
Free PMC Article
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