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Curr Opin Immunol. 2011 Aug;23(4):537-42. doi: 10.1016/j.coi.2011.05.005. Epub 2011 Jun 7.

The narrowing of the CD8 T cell repertoire in old age.

Author information

1
Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA. mblackman@trudeauinstitute.org

Abstract

Immune function declines progressively with age, resulting in increased susceptibility of the elderly to infection and impaired responses to vaccines. A diverse repertoire of T cells is essential for a vigorous immune response, and an important manifestation of immune aging is the progressive loss of repertoire diversity, predominantly among CD8 T cells in both mice and humans. Importantly, perturbations in the peripheral T cell repertoire, including reduction of the CD4:CD8 ratio and cytomegalovirus-driven T cell clonal expansions, make a major contribution to the 'immune risk phenotype' defined for humans, which predicts two-year mortality in very old individuals.

PMID:
21652194
PMCID:
PMC3163762
DOI:
10.1016/j.coi.2011.05.005
[Indexed for MEDLINE]
Free PMC Article

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