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Clin Genet. 2011 Aug;80(2):104-9. doi: 10.1111/j.1399-0004.2011.01722.x. Epub 2011 Jun 16.

Exome sequencing in Parkinson's disease.

Author information

1
Department of Molecular Neuroscience, Institute of Neurology, University College of London, London, UK. j.bras@ion.ucl.ac.uk

Abstract

Exome sequencing is rapidly becoming a fundamental tool for genetics and functional genomics laboratories. This methodology has enabled the discovery of novel pathogenic mutations causing mendelian diseases that had, until now, remained elusive. In this review, we discuss not only how we envisage exome sequencing being applied to a complex disease, such as Parkinson's disease, but also what are the known caveats of this approach.

PMID:
21651510
PMCID:
PMC3135730
DOI:
10.1111/j.1399-0004.2011.01722.x
[Indexed for MEDLINE]
Free PMC Article

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