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Nano Lett. 2011 Jul 13;11(7):2901-4. doi: 10.1021/nl201368w. Epub 2011 Jun 9.

Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1.

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Department of Neurobiology, The Life Sciences Institute, Faculty of Science, Hebrew University of Jerusalem, Israel.


The assembly of functional junction between nerve cells and electronic sensing pads is a critical problem in the construction of effective neuroelectronic hybrid systems. Here, we demonstrate for the first time that the ringlike Stable Protein 1 (Sp1) and its derivatives can be used to generate hydrophilic nanochannels in the plasma membrane of living cells. Since SP1-derivatives can be linked to both the plasma membrane, gold or silicon surfaces, they may serve to ohmically link between cells interior and electronic sensing devices.

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