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Wound Repair Regen. 2011 Jul-Aug;19(4):475-80. doi: 10.1111/j.1524-475X.2011.00701.x. Epub 2011 Jun 7.

Noncontact low-frequency ultrasound therapy in the treatment of chronic wounds: a meta-analysis.

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Clinical Research Limb Preservation and Tissue Repair, Department of Surgery, Boston University School of Medicine and Boston University Medical Center, Massachusetts, USA.


Our objective was to summarize and quantify the effects of a noncontact low-frequency ultrasound (NLFU) therapy on healing of chronic wounds. We performed a meta-analysis of eight published studies reporting effects of NLFU on wound size and healing rate of chronic wounds in 444 NLFU-treated patients. A search of the PubMed database was conducted in January 2010 and updated in October 2010. We used random-effects linear regression models to estimate the proportional reductions in wound area and volume and the proportion of wounds healed from baseline to last follow-up. In four studies (N=188) reporting change in wound area from baseline, NLFU was associated with 85.2% area reduction (95% CI 64.7%-97.6%) over a mean 7 weeks. In four studies (N=278) reporting reduction in wound volume, NLFU was associated with 79.7% volume reduction (95% CI 46.1%-98.8%) over a mean 12 weeks. In seven studies (N=429) reporting proportion of wounds healing by study end (mean time to healing 8.2 weeks; median 6.8 weeks), meta-analyzed healing rates over time suggest 32.7% of wounds healed on average by 6 weeks (95% CI 23.3%-42.1%) and 41.7% by 12 weeks. NLFU for treatment of chronic wounds was associated with consistent and substantial wound size reductions, as well as favorable rates of healing.

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