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Clin Exp Immunol. 2011 Sep;165(3):285-91. doi: 10.1111/j.1365-2249.2011.04427.x. Epub 2011 Jun 7.

Antibody fragments as tools in crystallography.

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  • 1Department of Structural Biology, UCB, Slough, UK.

Abstract

While antibody-based therapeutics have become firmly established as front-line drugs, the use of antibodies as research tools in small molecule drug discovery is still in its infancy. In this review we focus on the use of antibody fragments as crystallization chaperones to aid the structural determination of otherwise 'uncrystallizable' or 'undruggable' target proteins. We also highlight a potential application for this technology, in which antibody-mediated structures may be used to inform the design of new chemical entities.

PMID:
21649648
PMCID:
PMC3170977
DOI:
10.1111/j.1365-2249.2011.04427.x
[PubMed - indexed for MEDLINE]
Free PMC Article
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