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Biochem Biophys Res Commun. 1990 Jul 16;170(1):308-13.

Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle.

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Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.


Treatment with L-NG-monomethyl arginine (L-NMMA), an inhibitor of nitric oxide (NO) synthesis from L-arginine, suppressed the relaxant response of dog cerebral artery strips to transmural electrical stimulation and nicotine, as did oxyhemoglobin. The inhibition by L-NMMA was reversed or prevented by L-, but not D-, arginine. It is concluded that NO or an NO-related compound may play a crucial role in transmitting information from excited vasodilator nerves to cerebroarterial smooth muscle.

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