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Dev Dyn. 2011 Jul;240(7):1826-40. doi: 10.1002/dvdy.22669. Epub 2011 Jun 3.

Gene expression profile of the regeneration epithelium during axolotl limb regeneration.

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1
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.

Abstract

Urodele amphibians are unique among adult vertebrates in their ability to regenerate missing limbs. The process of limb regeneration requires several key tissues including a regeneration-competent wound epidermis called the regeneration epithelium (RE). We used microarray analysis to profile gene expression of the RE in the axolotl, a Mexican salamander. A list of 125 genes and expressed sequence tags (ESTs) showed a ≥1.5-fold expression in the RE than in a wound epidermis covering a lateral cuff wound. A subset of the RE ESTs and genes were further characterized for expression level changes over the time-course of regeneration. This study provides the first large scale identification of specific gene expression in the RE.

PMID:
21648017
PMCID:
PMC3297817
DOI:
10.1002/dvdy.22669
[Indexed for MEDLINE]
Free PMC Article
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