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Top Curr Chem. 2012;310:1-26. doi: 10.1007/128_2011_173.

Synthesis of polypeptides by ring-opening polymerization of α-amino acid N-carboxyanhydrides.

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  • 1Department of Materials Science and Engineering, University of Illinois, Champaign, IL 61801, USA.

Abstract

This chapter summarizes methods for the synthesis of polypeptides by ring-opening polymerization. Traditional and recently improved methods used to polymerize α-amino acid N-carboxyanhydrides (NCAs) for the synthesis of homopolypeptides are described. Use of these methods and strategies for the preparation of block copolypeptides and side-chain-functionalized polypeptides are also presented, as well as an analysis of the synthetic scope of different approaches. Finally, issues relating to obtaining highly functional polypeptides in pure form are detailed.

PMID:
21647839
DOI:
10.1007/128_2011_173
[PubMed - indexed for MEDLINE]
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