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Pediatr Rep. 2011 Feb 24;3(1):e6. doi: 10.4081/pr.2011.e6.

Current evidence of antifungal prophylaxis and therapy in pediatric patients.

Author information

  • 1Pediatric Hematology Oncology and Bone Marrow Unit, Ospedale Infantile Regina Margherita, Torino;

Abstract

Invasive fungal infections (IFI) are an important complication in pediatric haematological and oncological patients who undergo intensive chemotherapy for leukemia, solid tumour at advanced stage or relapsed, and hematopoietic stem cell transplantation. The incidence of IFI is lower than bacterial infection but mortality rate remains high. This review is designed to help paediatric oncologists in choosing the appropriate anti-fungal strategy and agents for prophylaxis, empirical, pre-emptive and specific therapy on the basis of published evidence.

KEYWORDS:

fungal infection; pediatric malignancy.

PMID:
21647279
PMCID:
PMC3103132
DOI:
10.4081/pr.2011.e6
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