Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin HIV AIDS. 2011 Jul;6(4):315-25. doi: 10.1097/COH.0b013e32834788e7.

HIV-1 treatment as prevention: the good, the bad, and the challenges.

Author information

1
Department of Epidemiology, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7030, USA.

Abstract

PURPOSE OF REVIEW:

This work focuses on the use of antiretroviral agents to prevent the sexual transmission of HIV-1.

RECENT FINDINGS:

Two randomized clinical trials demonstrated that antiretroviral agents provided before exposure to HIV-1 offer substantial protection, ostensibly directly proportional to the concentration of antiretroviral therapy (ART) in the genital secretions. Intense focus on the use of HIV treatment as prevention has led to publication of modeling exercises, ecological studies, and observational studies, most of which support the potential benefits of ART. However, the logistical requirements for successful use of ART for prevention are considerable.

SUMMARY:

ART will serve as a cornerstone of combination prevention of HIV-1. Continued research will be essential to measure anticipated benefits and to detect implementation barriers and untoward consequences of such a program, especially increases in primary ART resistance.

PMID:
21646878
PMCID:
PMC3666589
DOI:
10.1097/COH.0b013e32834788e7
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Support Center