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J Physiol. 2011 Aug 1;589(Pt 15):3703-8. doi: 10.1113/jphysiol.2011.207308. Epub 2011 Jun 6.

Automated measurement of zebrafish larval movement.

Author information

1
Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. eab25@pitt.edu

Abstract

The zebrafish is a powerful vertebrate model that is readily amenable to genetic, pharmacological and environmental manipulations to elucidate the molecular and cellular basis of movement and behaviour. We report software enabling automated analysis of zebrafish movement from video recordings captured with cameras ranging from a basic camcorder to more specialized equipment. The software, which is provided as open-source MATLAB functions, can be freely modified and distributed, and is compatible with multiwell plates under a wide range of experimental conditions. Automated measurement of zebrafish movement using this technique will be useful for multiple applications in neuroscience, pharmacology and neuropsychiatry.

PMID:
21646414
PMCID:
PMC3171879
DOI:
10.1113/jphysiol.2011.207308
[Indexed for MEDLINE]
Free PMC Article

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