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Pediatrics. 2011 Jul;128(1):111-26. doi: 10.1542/peds.2010-3875. Epub 2011 Jun 6.

Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?

Author information

  • 1Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. wrightcl@email.chop.edu

Abstract

Bronchopulmonary dysplasia (BPD) frequently complicates preterm birth and leads to significant long-term morbidity. Unfortunately, few therapies are known to effectively prevent or treat BPD. Ongoing research has been focusing on potential therapies to limit inflammation in the preterm lung. In this review we highlight recent bench and clinical research aimed at understanding the role of inflammation in the pathogenesis of BPD. We also critically assess currently used therapies and promising developments in the field.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00319956 NCT00433212 NCT00637169.

PMID:
21646264
PMCID:
PMC3124103
DOI:
10.1542/peds.2010-3875
[PubMed - indexed for MEDLINE]
Free PMC Article
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