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Mol Oncol. 2011 Aug;5(4):324-35. doi: 10.1016/j.molonc.2011.05.003. Epub 2011 May 19.

Centrosome clustering and chromosomal (in)stability: a matter of life and death.

Author information

1
Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center, Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. a.kraemer@dkfz.de

Abstract

Centrosome abnormalities occur commonly in cancer, and contribute to chromosomal instability and tumorigenesis. New evidence on a phylogenetically conserved mechanism termed 'centrosomal clustering' provides exciting insights into how cells with supernumerary centrosomes adapt to avoid lethal multipolar divisions. Here, we highlight the emerging molecular basis of centrosome clustering, and its impact on asymmetric divisions of stem cells, chromosomal (in)stability and malignant transformation. Finally, pharmacological inhibition of centrosome clustering promises to selectively target tumor cells.

PMID:
21646054
PMCID:
PMC5528316
DOI:
10.1016/j.molonc.2011.05.003
[Indexed for MEDLINE]
Free PMC Article

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