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J Neurochem. 1990 Aug;55(2):436-45.

Interferon suppresses sympathetic neuronal cell death caused by nerve growth factor deprivation.

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Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110.


Cultured rat sympathetic neurons die within 48 h after being deprived of nerve growth factor. Addition of interferons (IFN-alpha/beta or IFN-gamma) prevented the cell death in a dose-dependent manner. Upon longer periods of nerve growth factor deprivation, IFNs failed to maintain survival. Thus, IFNs retarded neuronal death, but did not prevent it. Ligand binding, autoradiography, and cross-linking experiments demonstrated the presence of specific IFN-gamma receptors on sympathetic neurons similar to those seen on other cell types. The possible relationships of the death-suppressing actions of IFNs are compared to the mechanisms of the antiviral or antiproliferative actions of IFNs.

[Indexed for MEDLINE]

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