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Zhonghua Gan Zang Bing Za Zhi. 2011 May;19(5):345-8. doi: 10.3760/cma.j.issn.1007-3418.2011.05.008.

[PD-1/PD-L1 expressions in liver tissues of patients with chronic HBV infection].

[Article in Chinese]

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Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.



To detect and compare the PD-1/PD-L1 (programmed death 1/programmed death 1 ligand) expressions in the liver tissues of chronic HBV infection patients in immune tolerant phase and those in immune clearance phase.


Liver biopsy samples were divided into two groups: 25 samples from patients in immune clearance phase and 19 samples from patients in immune tolerant phase. PD-1/PD-L1 expressions on T lymphocytes in these liver biopsy specimens were detected by immunohistochemistry method. Percentage of PD-1/PD-L1 positive cells among CD3 positive cells was calculated by semi-quantitative evaluation. Differences between the two groups were statistically analyzed.


PD-1/PD-L1 expressions were significantly higher in the patients in immune tolerant phase as compared to that in immune active phase (P < 0.05). No statistical difference found between the two groups for PD-L1 expression in Kupffer cells (P > 0.05).


PD-1/PD-L1 expression level can reflect the immune functions of chronic hepatitis B patients.

[Indexed for MEDLINE]

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