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Am J Respir Crit Care Med. 2011 Aug 15;184(4):401-6. doi: 10.1164/rccm.201103-0495PP.

Intersections between pulmonary development and disease.

Author information

1
Perinatal Institute, Divisions of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. jeff.whitsett@cchmc.org

Abstract

Recent advances in cellular, molecular, and developmental biology have revolutionized our concepts regarding the process of organogenesis that have important implications for our understanding of both lung formation and pulmonary disease pathogenesis. Pulmonary investigators have long debated whether developmental processes are recapitulated during normal repair of the lung or in the setting of chronic pulmonary diseases. Although the cellular events involved in lung morphogenesis and those causing pulmonary disease are likely to include processes that are distinct, there is increasing evidence that the pathogenesis of many lung disorders involves the same genetic machinery that regulates cell growth,specification, and differentiation during normal lung development.

PMID:
21642246
PMCID:
PMC3175542
DOI:
10.1164/rccm.201103-0495PP
[Indexed for MEDLINE]
Free PMC Article

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