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J Neurol Sci. 2011 Aug 15;307(1-2):34-40. doi: 10.1016/j.jns.2011.05.025. Epub 2011 Jun 8.

Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging.

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1
Department of Neurology, Nagoya University Graduate School of Medicine, Japan.

Abstract

BACKGROUND:

Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with impairment of frontotemporal functions such as cognition and behavior, but the behavioral changes associated with ALS are not well defined.

METHODS:

Twenty-one consecutive patients with sporadic ALS and 21 control subjects participated in the study. The Frontal System Behavior Scale (FrSBe) was used to assess behavioral change. Voxel-based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) were performed to explore the associations of brain degeneration with behavior. All patients were evaluated before the notification of ALS.

RESULTS:

FrSBe scores of ALS patients before notification were significantly increased compared to those of control subjects. Moreover, the FrSBe Apathy score of ALS patients significantly changed from pre- to post-illness (P<0.001). The severity of apathy was significantly correlated with atrophy in the prefrontal cortex, especially in the orbitofrontal (P=0.006) and dorsolateral prefrontal (P=0.006) cortices in VBM, and in the right frontal gyrus (P<0.001) in DTI.

CONCLUSIONS:

ALS patients exhibited apathy during the early course of the illness, the severity of which was significantly associated with frontal lobe involvement. These findings support the view that a continuum exits between ALS and frontotemporal dementia.

PMID:
21641004
DOI:
10.1016/j.jns.2011.05.025
[Indexed for MEDLINE]

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