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Physiol Behav. 2011 Oct 24;104(5):880-5. doi: 10.1016/j.physbeh.2011.05.023. Epub 2011 May 27.

Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease.

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Neurobehavioral Phenotyping Platform, Laboratory of Endocrinology and Genomics, CHUQ Research Center, Department of Molecular Medicine, Laval University, Québec, Canada.


Alzheimer's disease is characterized by deficits in social communication, associated with generalized apathy or agitation, as well as social memory. To assess social behaviors in 6-month-old male APPswe/PS1 bigenics relative to non-transgenic controls, the 3-chamber test was used, together with open-field and elevated plus-maze tests of exploration. APPswe/PS1 mice were less willing to engage in social interaction than wild-type, avoiding an unfamiliar stimulus mouse, probably not due to generalized apathy because in both tests of exploratory activity the mutants were hyperactive. This study reveals reduced "sociability" combined with hyperactivity in an APPswe/PS1 mouse model of Alzheimer dementia.

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