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Neuroimaging Clin N Am. 2011 May;21(2):327-44, xi. doi: 10.1016/j.nic.2011.02.008.

Imaging stroke patients with unclear onset times.

Author information

1
Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, MGH, 149 Thirteenth Street Suite 2301, Charlestown, MA 02129, USA. ona@nmr.mgh.harvard.edu

Abstract

Stroke is a leading cause of death and adult morbidity worldwide. By defining stroke symptom onset by the time the patient was last known to be well, many patients whose onsets are unwitnessed are automatically ineligible for thrombolytic therapy. Advanced brain imaging may serve as a substitute witness to estimate stroke onset and duration in those patients who do not have a human witness. This article reviews and compares some of these imaging-based approaches to thrombolysis eligibility, which can potentially expand the use of thrombolytic therapy to a broader population of acute stroke patients.

PMID:
21640303
PMCID:
PMC3109317
DOI:
10.1016/j.nic.2011.02.008
[Indexed for MEDLINE]
Free PMC Article
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